Looking for an academic partner for your discovery projects?
Looking for an academic partner for your discovery projects?
Ghent University offers a unique proposal: the collaboration between veterinarians, physicians and scientists from different disciplines present at Ghent University takes the research to a higher level and creates many opportunities for innovation. At our Faculty of Veterinary Medicine these innovations can be tested in our own facilities and on the target species.
Check what we can offer in these fields
Ghent University offers a unique proposal: the collaboration between veterinarians, physicians and scientists from different disciplines present at Ghent University takes the research to a higher level and creates many opportunities for innovation. At our Faculty of Veterinary Medicine these innovations can be tested in our own facilities and on the target species.
Check what we can offer in these fields
🔬 New research paper from the lab of provaxs member Prof. Dr. H. Favoreel entitled
28 Jan 2025
🦠Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread 🦠
Abstract
Gap junctions (GJs) play a pivotal role in intercellular communication between eukaryotic cells, including transfer of biomolecules that contribute to the innate and adaptive immune response. However, if and how viruses affect gap junction intercellular communication (GJIC) remains largely unexplored. Here, we describe how the alphaherpesvirus pseudorabies virus (PRV) triggers ERK1/2-mediated phosphorylation of the main gap junction component connexin 43 (Cx43) and closure of GJIC, which depends on the viral protein pUL46.
👀 Read the full text: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012895