top of page

🔬 New research paper from the lab of provaxs member Prof. Dr. H. Favoreel entitled

28 Jan 2025

🦠Pseudorabies virus infection triggers pUL46-mediated phosphorylation of connexin-43 and closure of gap junctions to promote intercellular virus spread 🦠

Abstract

Gap junctions (GJs) play a pivotal role in intercellular communication between eukaryotic cells, including transfer of biomolecules that contribute to the innate and adaptive immune response. However, if and how viruses affect gap junction intercellular communication (GJIC) remains largely unexplored. Here, we describe how the alphaherpesvirus pseudorabies virus (PRV) triggers ERK1/2-mediated phosphorylation of the main gap junction component connexin 43 (Cx43) and closure of GJIC, which depends on the viral protein pUL46.


👀 Read the full text: https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1012895

bottom of page