A recent study reports fresh insights into how bovine and porcine lactoferrin (LF) interact with porcine blood-derived monocytes. The researchers found that both bLF and pLF are readily internalized by monocytes and can translocate to the nucleus in a subset of these cells. Notably, iron saturation levels, proteolytic activity, and LPS-induced activation did not affect either LF uptake or nuclear translocation.

The team also assessed whether bLF could modulate LPS-induced inflammatory responses. Across all tested serotypes and concentrations, bLF did not reduce LPS-induced TNF-α secretion by monocytes.

These findings deepen the scientific understanding of LF’s interaction with innate immune cells and contribute valuable knowledge to its potential immunomodulatory properties.

🙏 Authors: provaxs members Prof. Dr. Eric Cox, Prof. Dr. Daisy Vanrompay, Prof. Dr. Bert Devriendt

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