12 Dec 2022
Different local, innate and adaptive immune responses are induced by two commercial Mycoplasma hyopneumoniae bacterins and an adjuvant alone
Mycoplasma hyopneumoniae is a major respiratory pathogen leading to economic losses in the intensive pig production worldwide. Vaccination is used to control clinical symptoms and minimize production losses. Recent data indicated that cellular immunity might play an important role in vaccine efficacy (https://bit.ly/3VJoJtb), however, the ability of current M. hyo vaccines to elicit T cell immunity is largely unexplored.
In this paper (https://bit.ly/3Fen8oe), we showed that two single shot vaccines reduced the M. hyo DNA load in lungs to a different extent, which correlated with a different ability of the vaccines to elicit polyfunctional cytokine-producing T cells. Interestingly, this different efficacy might in part be attributed to adjuvant-induced alterations in monocyte functions. We propose that next generation vaccines should elicit T cell immunity to protect animals against infections with Mycoplasma hyopneumoniae.
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