Looking for an academic partner for your discovery projects?
Looking for an academic partner for your discovery projects?
Ghent University offers a unique proposal: the collaboration between veterinarians, physicians and scientists from different disciplines present at Ghent University takes the research to a higher level and creates many opportunities for innovation. At our Faculty of Veterinary Medicine these innovations can be tested in our own facilities and on the target species.
Check what we can offer in these fields
Ghent University offers a unique proposal: the collaboration between veterinarians, physicians and scientists from different disciplines present at Ghent University takes the research to a higher level and creates many opportunities for innovation. At our Faculty of Veterinary Medicine these innovations can be tested in our own facilities and on the target species.
Check what we can offer in these fields
Therapeutics
Safe, effective and oral antiparasitics against protozoal infections
A purine nucleoside platform with the ability to act as antiprotozoal agents
The purine nucleoside platform is based on known and novel sugar- and purine ring scaffolds.
The nucleoside platform contains lead molecules for different indications. Proof of concept data at different stages (in vitro to in vivo) are available for various indications: Leishmania, Chagas, Nagana disease, Dourine, Surra, Blackhead, Cryptosporidium, and Toxoplasma species.
Proof of concept in various mouse models
As an example, we found 3’-deoxytubercidin analogues to be highly potent trypanocides against T. brucei spp. One analogue served as proof-of-concept in relevant mouse model of T. brucei infection. This derivative, 3’-deoxytubercidin, displays curative activity in both acute and CNS-stage infection in mice, highlighting that it is able to cross the blood-brain-barrier, likely a class effect.
Partnering
We seek development and marketing partners interested in developing nucleoside analogues as anti-parasitic against protozoal infections.